9th Annual WML Academic Symposium

Presenter(s): Dharmikkumar Vora
Title: Validation of developed HPLC-MS Method for Bioanalysis of Efavirenz
Developed under the guidance of Dr. Qinfeng “Sarah” Liu , College of Pharmacy & Health Sciences

Efavirenz is a HIV drug classified as non-nucleotide reverse transcriptase inhibitors (NNRTI). NNRTIs block HIV reverse transcriptase and therefore, prevent HIV from multiplying in the body. In this project, the HPLC-MS method developed for efavirenz bioanalysis in serum is being validated to confirm it complies to FDA guideline: accuracy within 100 ± 15%, linearity R^2 > 0.99, precision RSD ≤ 15%. Limit of detection (LOD), specificity and stability will also be validated.