9th Annual WML Academic Symposium

Presenter(s): Sujay Gurav
Title: Diffusion Studies of Oral Hypoglycemics Using Onion Membrane
Developed under the guidance of Dr. Antoine Al-Achi , College of Pharmacy & Health Sciences

Caco-2 cell lines have been widely used to study drug permeation. Replacing Caco-2 cell lines by the botanical membrane is a novel approach to study the drug permeation. The membrane of onion (Allium cepa) can be used as a membrane in Franz Diffusion Cell experiment. Drugs used in this experiment are Metformin and Glyburide, which are oral hypoglycemic agents that belong to the class biguanide and sulfonylurea respectively, used to treat Type 2 Diabetes. The permeability coefficient for both the drugs will be calculated and compared with the permeability coefficient of these drugs obtained using the Caco-2 cell monolayer model.