9th Annual WML Academic Symposium

Time: 1:30
Room: 301
Presenter(s): Florian Capobianco III, Cameron Davis, Renae Simons, Lauren Smith
Title: Cadaveric Case Study: Correlations Between Ischemic Stroke, Early On-Set Alzheimer's, and Down Syndrome
Developed under the guidance of Dr. Bruce Newton and Dr. Bonnie Brenseke , Osteopathic Medicine

In Down Syndrome (DS), overexpression of amyloid protein precursor (APP), a gene located in the critical region of chromosome 21, has been implicated in the development of early-onset Alzheimer’s Dementia (AD) via accumulation of Amyloid-β (Aβ), its proteolytic byproduct. Amyloid aggregation furthermore occurs in small blood vessels of the brain resulting in cerebral amyloid angiopathy (CAA). Consequently, the risk of ischemic or hemorrhagic stroke increases. In this case study, cadaveric dissection of a 59-year-old male with Down Syndrome revealed an ischemic stroke of the right precentral gyrus. Microscopic analysis of adjacent tissue exhibited neuritic plaque formation, a hallmark of AD.