Phospholipids are important constituents in the manufacture of liposomoes. They form the lipid bilayer of the liposomes. 1, 2- Dihexadeconyl-sn-glycero-3-phosphocholine (DPPC) is one such phospholipid which is the compound of interest here. It is important to know the thermal stability of this compound because during the manufacture of liposomes, they are subjected to higher temperatures.Studies suggested complex behavior for DPPC. Previous studies suggested the complex behavior of DPPC is due to moisture. Anhydrous DPPC may be a more reliable physical form with less thermal transitions. Heating is one technique by which moisture can be removed quickly. Heat treatment may cause chemical degradation, so an attempt is made to study the effect of heat on DPPC to see whether heating causes any chemical degradation. Development of stability indicating method using High Pressure Liquid Chromatography (HPLC) with an evaporative light scattering detector will allow qualitative and quantitative analysis of the DPPC stability.
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