3rd Annual Academic Symposium - Gana Talapureddy

This research involves preparation and evaluation of optimized cyproheptadine hydrochloride oral dissolving film strips (ODFS) at a dose of 2 mg per strip using LYCOAT® as the main film forming polymer. Glycerin and polysorbate 80 are used as plasticizer and solubilizer respectively, along with menthol as a penetration enhancer. Ethanol (96%) is used as co-solvent as cyproheptadine hydrochloride is not completely soluble in water. As a film stabilizer, locust bean gum is used. Full factorial design is used for optimization of formulation. Films obtained from optimized formula are evaluated for content, content uniformity, thickness, disintegration time, folding endurance, pH of solution obtained after dissolution of film strip, and moisture content. Being novel dosage forms, specific USP standard evaluation tests are not available for ODFS. Hence USP standard tests for content and content uniformity for tablets are employed in this research work.