Production of Clotrimazole nanoparticles by electro hydrodynamic atomization (EHDA) process
by Lokesh Chalapareddy
Developed under the guidance of:
Dr. Mali Gupta
Pharmaceutical Sciences
Electro hydrodynamic atomization, also known as Electrospraying is a process of liquid atomization by electric forces. Droplets produced are highly charged and self dispersing, that results in the absence of coagulation and agglomeration. Among various parameters, Q (flow rate) and K (liquid conductivity) are the most affecting, for controlling the droplet diameter. A flow rate of 0.01mL/min, a solvent of dichloromethane and methanol in the ratio 9:1, Clotrimazole in a concentration of 0.01mg/mL resulted in production of particles of size 146nm. Increasing the conductivity, voltage and surface tension of drug solution and decreasing the flow rate help in decreasing the particle size. The particles are analyzed by HPLC and GC for percentage recovery and the presence of organic solvents respectively. Stability studies are performed for the produced particles.
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